Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | SUCNR1 | Q9BXA5 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GCG | P01275 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184923 | 0.88 | CYP2C19 (0.64) | CYP2C19PTGDR2FFAR4FFAR1SLC6A4 | |
| SCHEMBL3111571 | 0.87 | KMT2A (0.56) | PTGDR2FFAR4FFAR1KMT2APTGS1 | |
| SCHEMBL3540535 | 0.86 | SUCNR1 (0.56) | CYP2C19PTGDR2FFAR4FFAR1SLC6A4 | |
| SCHEMBL28888278 | 0.86 | ABCC4 (0.44) | CYP2C19FFAR4FFAR1KMT2APTGS1 | |
| SCHEMBL29636261 | 0.86 | ABCC4 (0.44) | CYP2C19FFAR4FFAR1KMT2APTGS1 | |
| SCHEMBL7600170 | 0.84 | FFAR1 (0.46) | CYP2C19PTGDR2FFAR4FFAR1SUCNR1 | |
| SCHEMBL7410920 | 0.84 | KMT2A (0.53) | PTGDR2FFAR4FFAR1KMT2APTGS1 | |
| SCHEMBL6598295 | 0.81 | KCNA5 (0.44) | CYP2C19KMT2AMAPTNPC1ALDH1A1 | |
| SCHEMBL9890714 | 0.80 | CYP2C19 (0.49) | CYP2C19PTGDR2FFAR4FFAR1SLC6A4 | |
| SCHEMBL9890715 | 0.80 | CYP2C19 (0.49) | CYP2C19PTGDR2FFAR4FFAR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017672-B1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 2002-11-27 | — | — | EP | disclosed |
| US-6127414-A | NPY antagonists | ASTRA AKTIEBOLAG (SE) | 2000-10-03 | — | — | US | disclosed |
| EP-1017672-A1 | NEW NPY ANTAGONISTS | AstraZeneca AB (SE) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015498-A1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 1999-04-01 | — | — | WO | disclosed |