Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | DPYD | Q12882 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487928 | 0.83 | ALDH1A1 (0.42) | ALDH1A1DPYDMAPTGAAATAD2 | |
| SCHEMBL20317375 | 0.71 | ACHE (0.42) | ALDH1A1DPYDMAPTCYP19A1TSHR | |
| SCHEMBL20317374 | 0.70 | ALDH1A1 (0.41) | ALDH1A1DPYDMAPTGAAATAD2 | |
| SCHEMBL17197927 | 0.69 | MAPT (0.40) | ALDH1A1MAPTGAALMNASMN1; SMN2 | |
| SCHEMBL7488455 | 0.68 | ATAD2 (0.40) | ALDH1A1DPYDGAAATAD2LMNA | |
| SCHEMBL7831877 | 0.68 | KMT2A (0.39) | ALDH1A1DPYDMAPTGAAATAD2 | |
| SCHEMBL3561548 | 0.67 | DPYD (0.45) | ALDH1A1DPYDMAPTGAAATAD2 | |
| SCHEMBL27791302 | 0.67 | HTR2C (0.56) | ALDH1A1MAPTGAALMNAPMP22 | |
| SCHEMBL23664585 | 0.66 | ALDH1A1 (0.40) | ALDH1A1DPYDMAPTGAALMNA | |
| SCHEMBL21025735 | 0.66 | MAPT (0.37) | ALDH1A1MAPTGAALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000038-B1 | NOVEL PYRIMIDIN DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-06 | — | — | EP | disclosed |
| EP-1000038-A1 | NOVEL PYRIMIDIN DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005123-A1 | NOVEL PYRIMIDIN DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-02-04 | — | — | WO | disclosed |