Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.51 |
| ▸ | DRD1 | P21728 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5246352 | 0.71 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3DRD1CYP1A2 | |
| SCHEMBL10958176 | 0.68 | CHRNB2 (0.38) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5244478 | 0.68 | SLC6A4 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| Hydrochloric Acid SCHEMBL9623775 | 0.68 | SIGMAR1 (0.39) | SLC6A2SLC6A4SLC6A3DRD1KDM4E | |
| SCHEMBL7591358 | 0.67 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL13079925 | 0.66 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3MAPTPMP22 | |
| SCHEMBL11619884 | 0.66 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3DRD1KDM4E | |
| SCHEMBL27571729 | 0.65 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL6047844 | 0.65 | GID4 (0.55) | SLC6A2SLC6A4SLC6A3DRD1MAOB | |
| SCHEMBL11643969 | 0.65 | SLC6A2 (0.60) | SLC6A2SLC6A4SLC6A3CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246805-A1 | 4-PHENYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | ALBANY MOLECULAR RESEARCH, INC. (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001032624-A1 | 4-PHENYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-05-10 | — | — | WO | disclosed |