Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 17/20 | 0.63 |
| ▸ | HTR2C | P28335 | 17/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 16/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7602613 | 0.92 | ADRA1A (0.61) | HTR2AHTR2CSLC6A4DRD2DRD3 | |
| SCHEMBL7599561 | 0.89 | ADRA1D (0.55) | HTR2AHTR2CSLC6A4DRD2DRD3 | |
| SCHEMBL7601484 | 0.84 | DRD2 (0.70) | HTR2ASLC6A4DRD2DRD3ADRA1A | |
| SCHEMBL7601660 | 0.84 | ADRA1D (0.56) | DRD2DRD3ADRA1A | |
| SCHEMBL7601974 | 0.84 | DRD2 (0.61) | DRD2DRD3ADRA1A | |
| SCHEMBL7600435 | 0.83 | DRD2 (0.74) | SLC6A4DRD2DRD3 | |
| SCHEMBL7601949 | 0.83 | ADRA1D (0.62) | SLC6A4DRD2DRD3ADRA1A | |
| SCHEMBL7601947 | 0.82 | KCNH2 (0.59) | HTR2AHTR2CSLC6A4DRD2DRD3 | |
| SCHEMBL7599519 | 0.82 | DRD2 (0.53) | HTR2AHTR2CSLC6A4DRD2DRD3 | |
| SCHEMBL7596111 | 0.82 | ADRA1D (0.56) | DRD2DRD3ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891344-B1 | ALPHA-1 ADRENERGIC RECEPTOR ANTAGONISTS | SOD CONSEILS RECH APPLIC (FR) | 2002-12-18 | — | — | EP | disclosed |
| US-6300499-B1 | α1-adrenergic receptor antagonists | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-10-09 | — | — | US | disclosed |
| EP-0891344-A1 | ALPHA 1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997037983-A1 | α1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1997-10-16 | — | — | WO | disclosed |