Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 10/20 | 0.39 |
| ▸ | NAAA | Q02083 | 9/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28459084 | 0.87 | PIK3CD (0.39) | PIK3CDKDM4EFAAHNAAASMN1; SMN2 | |
| SCHEMBL2695924 | 0.82 | PIK3CD (0.54) | PIK3CDKDM4EFAAHNAAASMN1; SMN2 | |
| SCHEMBL8472458 | 0.82 | PIK3CD (0.42) | PIK3CDKDM4EFAAHNAAASMN1; SMN2 | |
| SCHEMBL7921220 | 0.71 | ITGB1 (0.37) | KMT2AKCNN4 | |
| SCHEMBL2190750 | 0.70 | TNKS (0.36) | KDM4EFAAHNAAAKMT2AKCNN4 | |
| SCHEMBL13594302 | 0.68 | NAAA (0.43) | FAAHNAAAKMT2A | |
| SCHEMBL28877645 | 0.68 | NAAA (0.50) | FAAHNAAASMN1; SMN2 | |
| SCHEMBL24737459 | 0.68 | ALOX5 (0.41) | KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL8092347 | 0.68 | HTT (0.41) | KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL783215 | 0.67 | PIK3CD (0.64) | PIK3CDKDM4ENAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880676-B1 | 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | PFIZER (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2020100027-A1 | 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | PFIZER INC. (US) | 2020-05-22 | — | — | WO | disclosed |
| US-6448412-B1 | COMBINATORIAL CHEMISTRY LIBRARIES | SPHERE BIOSYSTEMS, INC. | 2002-09-10 | — | — | US | disclosed |
| US-6399785-B1 | BIOSYNTHESIS; LIBRARY OF COMPOUNDS; DRUGS | C-SIXTY, INC. (CA) | 2002-06-04 | — | — | US | disclosed |
| US-6162926-A | Multi-substituted fullerenes and methods for their preparation and characterization | SPHERE BIOSYSTEMS, INC. (US) | 2000-12-19 | — | — | US | disclosed |
| WO-1996036631-A1 | MULTIPLY-SUBSTITUTED FULLERENES AND METHODS FOR THEIR PREPARATION AND CHARACTERIZATION | SPHERE BIOSYSTEMS, INC. (US) | 1996-11-21 | — | — | WO | disclosed |