Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | CELA1 | Q9UNI1 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11611744 | 0.68 | GRN (0.43) | MEN1KMT2AMAPTGAASMN1; SMN2 | |
| SCHEMBL8890259 | 0.65 | FLT1 (0.48) | SMN1; SMN2ALDH1A1PDE4BKDM4E | |
| SCHEMBL23402494 | 0.65 | MEN1 (0.50) | ESR1MEN1KMT2AMAPTGAA | |
| SCHEMBL23399460 | 0.65 | KMT2A (0.48) | MEN1KMT2AMAPTGAASMN1; SMN2 | |
| SCHEMBL7600106 | 0.65 | ADORA3 (0.42) | MEN1KMT2AMAPTGAASMN1; SMN2 | |
| SCHEMBL3847408 | 0.64 | MET (0.60) | MEN1KMT2ASMN1; SMN2PDE4APDE4B | |
| SCHEMBL3849216 | 0.64 | SMN1; SMN2 (0.53) | MEN1KMT2AMAPTGAASMN1; SMN2 | |
| SCHEMBL23399515 | 0.63 | MEN1 (0.52) | ESR1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL5380585 | 0.63 | KDM4E (0.53) | MAPTGAAALDH1A1KDM4E | |
| SCHEMBL7539974 | 0.63 | CYP19A1 (0.46) | BACE1GAASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |