Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11615729 | 0.77 | TP53 (0.45) | POLBGAAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11614807 | 0.74 | PTGDR2 (0.42) | GAAKMT2AMEN1MAPT | |
| SCHEMBL11619251 | 0.72 | SLC22A12 (0.51) | POLBKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL1195231 | 0.69 | PTGDR2 (0.62) | GAA | |
| SCHEMBL11616262 | 0.69 | PTGDR2 (0.47) | POLBKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL11614313 | 0.69 | NPC1 (0.44) | GAAKMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL11611800 | 0.69 | PTGDR2 (0.45) | GAAKMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL27739429 | 0.68 | ALDH1A1 (0.49) | GRNSORT1POLBGAAKMT2A | |
| SCHEMBL7600100 | 0.68 | BACE1 (0.36) | GAAKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL717987 | 0.68 | NPC1 (0.65) | POLBGAAKMT2APTGS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117145-A | DIURETIC, HYPOTENSIVE, ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4117143-A | USED AS ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4113957-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-12 | — | — | US | disclosed |