Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 7/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.53 |
| ▸ | GSPT1 | P15170 | 4/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407934 | 0.94 | DDB1 (0.46) | DDB1CRBNGSPT1EPHX2SMN1; SMN2 | |
| SCHEMBL7523759 | 0.94 | MAPT (0.46) | DDB1CRBNGSPT1EPHX2SMN1; SMN2 | |
| SCHEMBL7518349 | 0.89 | NAMPT (0.47) | DDB1CRBNGSPT1EPHX2SMN1; SMN2 | |
| SCHEMBL7516737 | 0.89 | POLB (0.48) | DDB1CRBNSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL7516813 | 0.89 | NPC1 (0.53) | SMN1; SMN2RAB9ANPC1BACE1ALDH1A1 | |
| SCHEMBL7518350 | 0.89 | RAB9A (0.51) | EPHX2SMN1; SMN2RAB9ANPC1BACE1 | |
| SCHEMBL7522639 | 0.88 | RAB9A (0.55) | SMN1; SMN2RAB9ANPC1BACE1ALDH1A1 | |
| SCHEMBL7517806 | 0.88 | F7 (0.46) | DDB1CRBNSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL7523985 | 0.88 | BACE1 (0.45) | DDB1CRBNEPHX2SMN1; SMN2RAB9A | |
| SCHEMBL7523275 | 0.88 | ALDH1A1 (0.45) | DDB1CRBNEPHX2SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183252-B2 | Heterocyclic aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2012-05-22 | — | — | US | disclosed |
| US-8178513-B2 | Heterocyclic aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100292203-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION | 2010-11-18 | — | — | US | disclosed |
| US-20090306047-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292203-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | CHRM1, CHRM2, PRSS1 | DDB1 4188/4885CRBN 2009/4885GSPT1 1480/4885 |
| US-20090306047-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | PRSS1, BCHE, CTSZ | DDB1 3876/4885CRBN 1420/4885GSPT1 1475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.