Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 11/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.54 |
| ▸ | ITGB8 | P26012 | 6/20 | 0.42 |
| ▸ | ITGB6 | P18564 | 5/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 5/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7577451 | 1.00 | ITGAV (0.54) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7597015 | 1.00 | ITGAV (0.54) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7597852 | 0.87 | ITGAV (0.47) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7596086 | 0.87 | ITGAV (0.47) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7584472 | 0.87 | ITGAV (0.47) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7589889 | 0.86 | ITGAV (0.54) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7594711 | 0.86 | ITGAV (0.54) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL7554383 | 0.86 | ITGAV (0.54) | ITGAVITGB3ITGB8ITGB6ITGA5 | |
| SCHEMBL4376692 | 0.86 | ITGB3 (0.44) | ITGAVITGB3CXCR3PDE4APDE4B | |
| SCHEMBL7559347 | 0.85 | ITGAV (0.49) | ITGAVITGB3ITGB8ITGB6ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040111-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999031099-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | disclosed |