SCHEMBL7601084

NC(=O)[C@@H](CCCNC(=NC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1)N(C(=O)C(c1ccccc1)c1ccccc1)[C@@H](CO)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 16)

	gene	UniProt	supporting neighbours	confidence
▸	FOLH1	Q04609	4/20	0.37

▸	HTT	P42858	1/20	0.35

▸	TPSAB1	Q15661	2/20	0.35

▸	SLC1A3	P43003	1/20	0.35

▸	SLC1A1	P43005	1/20	0.35

▸	SIRT2	Q8IXJ6	1/20	0.34

▸	KEAP1	Q14145	2/20	0.34

▸	NFE2L2	Q16236	2/20	0.34

▸	DPP8	Q6V1X1	1/20	0.34

▸	DPP7	Q9UHL4	1/20	0.34

▸	MMP2	P08253	1/20	0.33

▸	MMP9	P14780	1/20	0.33

▸	MEN1	O00255	1/20	0.33

▸	KMT2A	Q03164	1/20	0.33

▸	OPRK1	P41145	1/20	0.33

▸	ANPEP	P15144	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7597349	1.00	FOLH1 (0.37)	FOLH1HTTTPSAB1SLC1A3SLC1A1
SCHEMBL7596771	0.94	CA1 (0.38)	FOLH1SIRT2
SCHEMBL7597936	0.90	FOLH1 (0.40)	FOLH1HTTTPSAB1SLC1A3SLC1A1
SCHEMBL7601629	0.90	FOLH1 (0.40)	FOLH1HTTTPSAB1SLC1A3SLC1A1
SCHEMBL7600933	0.89	FOLH1 (0.46)	FOLH1HTTSLC1A3SLC1A1KEAP1
SCHEMBL7598858	0.89	FOLH1 (0.46)	FOLH1HTTSLC1A3SLC1A1KEAP1
SCHEMBL7600478	0.87	FOLH1 (0.38)	FOLH1HTTTPSAB1SLC1A3SLC1A1
SCHEMBL7597915	0.87	FOLH1 (0.38)	FOLH1HTTTPSAB1SLC1A3SLC1A1
SCHEMBL7599024	0.85	CA1 (0.42)	FOLH1KMT2A
SCHEMBL7595006	0.85	CA1 (0.42)	FOLH1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1017672-B1	NEW NPY ANTAGONISTS	ASTRAZENECA AB (SE)	2002-11-27	—	—	EP	disclosed