Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7601629 | 1.00 | FOLH1 (0.40) | FOLH1SIRT2HTTSLC1A3SLC1A1 | |
| SCHEMBL7597915 | 0.97 | FOLH1 (0.38) | FOLH1SIRT2HTTSLC1A3SLC1A1 | |
| SCHEMBL7600478 | 0.97 | FOLH1 (0.38) | FOLH1SIRT2HTTSLC1A3SLC1A1 | |
| SCHEMBL7599024 | 0.94 | CA1 (0.42) | FOLH1CYP3A4TSHRALDH1A1KMT2A | |
| SCHEMBL7595006 | 0.94 | CA1 (0.42) | FOLH1CYP3A4TSHRALDH1A1KMT2A | |
| SCHEMBL7600882 | 0.93 | TRPM8 (0.41) | FOLH1MEN1KMT2A | |
| SCHEMBL7600973 | 0.92 | MMP2 (0.37) | FOLH1SIRT2TPSAB1LMNAMEN1 | |
| SCHEMBL7601084 | 0.90 | FOLH1 (0.37) | FOLH1SIRT2HTTSLC1A3SLC1A1 | |
| SCHEMBL7597349 | 0.90 | FOLH1 (0.37) | FOLH1SIRT2HTTSLC1A3SLC1A1 | |
| SCHEMBL7595812 | 0.88 | FOLH1 (0.49) | FOLH1HTTSLC1A3SLC1A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017672-B1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 2002-11-27 | — | — | EP | disclosed |
| EP-1017672-A1 | NEW NPY ANTAGONISTS | AstraZeneca AB (SE) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015498-A1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 1999-04-01 | — | — | WO | disclosed |