Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 4/20 | 0.37 |
| ▸ | SCD | O00767 | 3/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14833412 | 0.81 | KDM4E (0.41) | HTR2ASSTR4SCD | |
| SCHEMBL27889106 | 0.77 | HRH1 (0.40) | HTR2CKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6446140 | 0.75 | HTR2C (0.50) | HTR2CHTR2AHTR2B | |
| SCHEMBL2819314 | 0.70 | HTR1A (0.58) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL1782071 | 0.70 | HTR1A (0.58) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL7888184 | 0.70 | HTR1A (0.58) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL22462919 | 0.69 | LTA4H (0.46) | HTR1ASSTR4SCDDRD2 | |
| Hydrochloric Acid SCHEMBL2947998 | 0.69 | HTR1A (0.57) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL1230447 | 0.69 | SLC6A2 (0.54) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL6255525 | 0.69 | SIGMAR1 (0.43) | HTR2CHTR2AKCNH2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246820-A1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049683-A1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2001-07-12 | — | — | WO | disclosed |