Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 6/20 | 0.41 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6182218 | 0.87 | CTSL (0.50) | LMNACTSBCTSLCTSSCTSK | |
| SCHEMBL7488759 | 0.78 | CTSK (0.49) | LMNACTSBCTSLCTSSCTSK | |
| SCHEMBL7490691 | 0.78 | CTSB (0.51) | LMNACTSBCTSLCTSSCTSK | |
| SCHEMBL6181779 | 0.77 | CTSK (0.58) | CTSBCTSLCTSSCTSK | |
| SCHEMBL6182064 | 0.77 | CTSB (0.45) | LMNACTSBCTSLCTSSCTSK | |
| SCHEMBL6185103 | 0.77 | CTSB (0.44) | LMNACTSBCTSLCTSSCTSK | |
| SCHEMBL6181621 | 0.76 | SMN1; SMN2 (0.55) | LMNACTSBALDH1A1MAPT | |
| SCHEMBL7486512 | 0.76 | CTSB (0.50) | CTSBCTSLCTSSCTSKNPC1 | |
| SCHEMBL6183627 | 0.75 | GAA (0.52) | LMNAGAANPC1ALDH1A1MAPT | |
| SCHEMBL7601395 | 0.74 | JAK2 (0.46) | LMNACTSBCTSLCTSSGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161415-A2 | N-CYANOMETHYLAMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055126-A2 | N-CYANOMETHYLAMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |