Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28405457 | 1.00 | TSHR (0.43) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL20919654 | 1.00 | TSHR (0.43) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL17361237 | 1.00 | TSHR (0.43) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL29014086 | 1.00 | TSHR (0.43) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL28505904 | 1.00 | TSHR (0.43) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL18886361 | 1.00 | TSHR (0.43) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL24835739 | 0.89 | TSHR (0.50) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL30552236 | 0.89 | TSHR (0.50) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL31591142 | 0.89 | TSHR (0.50) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL22326325 | 0.89 | LMNA (0.40) | TSHRLMNACHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | claimed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | claimed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | claimed |
| CN-116102534-B | Covalent PARP PROTACs derivatives and their use | 四川大学 | 2024-06-04 | — | — | CN | disclosed |
| US-20240174959-A1 | NOVEL POLYMER-COATED CROSSLINKED ALGINATE GEL FIBER | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2024-05-30 | — | — | US | disclosed |
| CN-118103074-A | Cytotoxic targeting chimeras for CCR2 expressing cells | 葛兰素史克知识产权发展有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118076595-A | Five-membered and six-membered compound, preparation method, pharmaceutical composition and application | 杭州多域生物技术有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-117980308-A | Compound having photocleavable site, joined body, and screening method using same | 中外制药株式会社 | 2024-05-03 | — | — | CN | disclosed |
| EP-4361249-A1 | NOVEL POLYMER-COATED CROSSLINKED ALGINATE GEL FIBER | Mochida Pharmaceutical Co., Ltd. (JP) | 2024-05-01 | — | — | EP | disclosed |
| CN-117957218-A | Targeted protein degradation using bifunctional compounds that bind to ubiquitin ligases and target MCL-1 proteins | 凯普托尔治疗学股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| US-20240132854-A1 | NOVEL MULTILAYER POLYMER-COATED CROSSLINKED ALGINATE GEL FIBER | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2024-04-25 | — | — | US | disclosed |
| CN-111606969-A | PARP1 protein degradation agent and application thereof in tumor resistance | 四川大学 | 2020-09-01 | — | — | CN | disclosed |
| WO-2020038415-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI), INC. (CN) | 2020-02-27 | — | — | WO | disclosed |
| CN-110240629-A | Protein degradation targets BCR-ABL compound and its antitumor application thereof | 上海科技大学 | 2019-09-17 | — | — | CN | disclosed |
| WO-2016206101-A1 | METALLO-BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-29 | — | — | WO | disclosed |
| CN-106163568-A | Antibody drug conjugates (ADC) containing spindle kinesin (KSP) | 拜耳制药股份公司 | 2016-11-23 | — | — | CN | disclosed |
| WO-2012082574-A1 | MEMBRANE LYTIC POLY(AMIDO AMINE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES | MERCK SHARP & DOHME CORP. (US) | 2012-06-21 | — | — | WO | disclosed |
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132854-A1 | NOVEL MULTILAYER POLYMER-COATED CROSSLINKED ALGINATE GEL FIBER | IAPP, COG6, IL6 | TSHR 3811/4885LMNA 4163/4885CHRM2 836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.