Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7600217 | 0.86 | NPC1 (0.58) | LMNATDP1RAB9AMEN1KMT2A | |
| SCHEMBL8282497 | 0.80 | NPC1 (0.57) | LMNATDP1RAB9AMEN1KMT2A | |
| SCHEMBL7602756 | 0.77 | NPC1 (0.52) | LMNATDP1RAB9AMEN1KMT2A | |
| Carbamic Acid SCHEMBL7601763 | 0.77 | LMNA (0.51) | LMNATDP1SMN1; SMN2CA2CA12 | |
| SCHEMBL27583343 | 0.77 | NPC1 (0.54) | LMNATDP1RAB9AMEN1KMT2A | |
| SCHEMBL12248256 | 0.75 | CA12 (0.59) | LMNATDP1RAB9AMEN1KMT2A | |
| SCHEMBL1044520 | 0.75 | LMNA (0.55) | LMNATDP1RAB9AMEN1KMT2A | |
| SCHEMBL28340854 | 0.75 | CA12 (0.59) | LMNATDP1RAB9AMEN1KMT2A | |
| SCHEMBL1281463 | 0.75 | CA12 (0.59) | LMNATDP1RAB9AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7603533 | 0.74 | CA12 (0.58) | LMNARAB9AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | claimed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | claimed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | claimed |