Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27572428 | 0.81 | NPC1 (0.54) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL8282497 | 0.79 | NPC1 (0.57) | NPC1RAB9AMEN1KMT2ACA12 | |
| Carbamic Acid SCHEMBL7602744 | 0.78 | HCAR2 (0.58) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL7601766 | 0.77 | LMNA (0.51) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL1281463 | 0.76 | CA12 (0.59) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL30159033 | 0.76 | CA12 (0.52) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL11560271 | 0.76 | CA12 (0.52) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL28124577 | 0.76 | THRB (0.58) | NPC1RAB9AMEN1KMT2ACA12 | |
| Hydrochloric Acid SCHEMBL7603533 | 0.75 | CA12 (0.58) | NPC1RAB9AMEN1KMT2ACA12 | |
| SCHEMBL27583343 | 0.75 | NPC1 (0.54) | NPC1RAB9AMEN1KMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | claimed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | claimed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | claimed |