Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606125 | 0.88 | PDE4B (0.39) | PGRSMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL1080676 | 0.87 | PARP1 (0.36) | PARP1PTGES | |
| SCHEMBL7601260 | 0.85 | PGR (0.41) | PGRSMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL7606107 | 0.84 | KMT2A (0.44) | PGRKMT2AMEN1ALDH1A1PTGES | |
| SCHEMBL7602872 | 0.83 | PGR (0.40) | PGRSMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL1178111 | 0.81 | MAOB (0.33) | PARP1PDE4BPTGES | |
| SCHEMBL1080257 | 0.80 | MAOB (0.35) | KMT2AMEN1ALDH1A1PDE4BLMNA | |
| SCHEMBL7601064 | 0.80 | PTGES (0.59) | SMN1; SMN2KMT2AMEN1GAAPTGES | |
| SCHEMBL7605922 | 0.79 | KMT2A (0.42) | PGRKMT2APDE4BPDE4APDE4C | |
| SCHEMBL12872121 | 0.79 | MAOB (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268625-B1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | Bayer Pharma AG (DE) | 2012-05-16 | — | — | EP | disclosed |