Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476620 | 1.00 | MAPT (0.42) | MAPTRXFP1RXRANR1H2NR1H3 | |
| SCHEMBL11235133 | 0.96 | HSD17B10 (0.43) | MAPTRXRANR1H2NR1H3HSD17B10 | |
| SCHEMBL9649858 | 0.83 | BCHE (0.42) | RXRABCHEACHE | |
| SCHEMBL7611219 | 0.82 | ACACB (0.49) | MAPTRXFP1RXRAFFAR4HSD17B10 | |
| SCHEMBL12050814 | 0.82 | BCHE (0.53) | SIGMAR1BCHEACHEADRA1ASLC6A3 | |
| SCHEMBL20705409 | 0.80 | ACACB (0.41) | BCHEACHE | |
| SCHEMBL11233737 | 0.78 | HSD17B10 (0.54) | MAPTRXFP1RXRAHSD17B10SIGMAR1 | |
| SCHEMBL11245622 | 0.77 | FAAH (0.33) | BCHEACHEALOX5 | |
| SCHEMBL7603743 | 0.77 | ATM (0.44) | MAPTRXFP1RXRANR1H2NR1H3 | |
| SCHEMBL7603740 | 0.77 | ATM (0.44) | MAPTRXFP1RXRANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820984-B1 | Activated amphetamines | ROCHE DIAGNOSTICS GMBH (DE) | 2002-03-27 | — | — | EP | disclosed |
| US-5976812-A | Activated amphetamines | ROCHE DIAGNOSTICS GMBH (DE) | 1999-11-02 | — | — | US | disclosed |
| EP-0820984-A1 | Activated amphetamines | Roche Diagnostics GmbH (DE) | 1998-01-28 | — | — | EP | disclosed |