Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.73 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 8/20 | 0.71 |
| ▸ | NPC1 | O15118 | 8/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.71 |
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 6/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.61 |
| ▸ | RELA | Q04206 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | CASP3 | P42574 | 1/20 | 0.61 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10401986 | 0.86 | MTNR1A (0.71) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6985119 | 0.85 | HDAC3 (0.59) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL21963810 | 0.85 | MTNR1A (0.54) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14409677 | 0.85 | MTNR1A (0.69) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10316528 | 0.85 | MTNR1A (1.00) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11492938 | 0.83 | TEAD1 (0.73) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL18281767 | 0.83 | L3MBTL1 (0.69) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14241826 | 0.82 | MTNR1A (0.70) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8017839 | 0.80 | MTNR1A (0.63) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10421848 | 0.80 | RAB9A (0.72) | MTNR1AMTNR1BRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | disclosed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | disclosed |
| US-4914206-A | ANTIBIOTICS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-04-03 | — | — | US | disclosed |
| EP-0226896-A2 | Lankacidin derivatives and production thereof | Takeda Chemical Industries, Ltd. (JP) | 1987-07-01 | — | — | EP | disclosed |