Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 10/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404661 | 0.81 | ELANE (0.33) | KDM5A | |
| SCHEMBL7405849 | 0.78 | ELANE (0.33) | KDM5A | |
| SCHEMBL7410357 | 0.72 | PDK2 (0.32) | — | |
| SCHEMBL8615680 | 0.72 | ELANE (0.34) | — | |
| SCHEMBL8615757 | 0.70 | ELANE (0.33) | — | |
| SCHEMBL8609833 | 0.69 | ELANE (0.35) | — | |
| SCHEMBL7401912 | 0.61 | ELANE (0.37) | — | |
| SCHEMBL11048771 | 0.58 | ALDH1A1 (0.46) | — | |
| SCHEMBL19897249 | 0.58 | ALDH1A1 (0.46) | — | |
| SCHEMBL11049073 | 0.58 | ALDH1A1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997010243-A1 | 2-(PYRAZOL-5-YL-OXYMETHYL)-1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI (US) | 1997-03-20 | — | — | WO | disclosed |