Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 3/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | SELP | P16109 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7602907 | 0.85 | CASR (0.46) | CASRS1PR1SLC6A3CYP2D6SLC6A2 | |
| SCHEMBL7603918 | 0.83 | CASR (0.41) | CASRS1PR1S1PR5SLC6A3CYP2D6 | |
| SCHEMBL28460083 | 0.77 | FFAR1 (0.57) | FFAR1FFAR4CASRS1PR1S1PR5 | |
| SCHEMBL23077756 | 0.75 | CYP1A2 (0.49) | FFAR1FFAR4HSD17B10CYP1A2S1PR1 | |
| SCHEMBL30229736 | 0.75 | FFAR4 (0.50) | FFAR1FFAR4RXRARXRBRXRG | |
| SCHEMBL3455979 | 0.72 | MTNR1A (0.46) | FFAR1FFAR4HSD17B10CASRS1PR1 | |
| SCHEMBL22954039 | 0.70 | KCNH2 (0.48) | HSD17B10KCNH2SMN1; SMN2 | |
| SCHEMBL2723153 | 0.70 | RXRA (0.54) | FFAR1FFAR4HSD17B10S1PR1RXRA | |
| SCHEMBL503571 | 0.70 | PLAAT3 (0.61) | CYP1A2SELPPPARGPPARA | |
| SCHEMBL22068710 | 0.70 | KCNH2 (0.44) | FFAR1FFAR4CASRS1PR1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395919-B1 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION | 2002-05-28 | — | — | US | disclosed |
| EP-1070048-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-1070048-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999051569-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |