Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7603982 | 0.90 | MEN1 (0.46) | MEN1KMT2ATDP1POLBALOX5 | |
| SCHEMBL7603981 | 0.90 | MEN1 (0.46) | MEN1KMT2ATDP1POLBALOX5 | |
| SCHEMBL14375288 | 0.85 | POLB (0.45) | MEN1KMT2ATDP1POLBALOX5 | |
| SCHEMBL4301056 | 0.85 | MEN1 (0.45) | MEN1KMT2ATDP1POLBGABRA1 | |
| SCHEMBL3958628 | 0.82 | GABRA1 (0.55) | MEN1KMT2ATDP1POLBALOX5 | |
| SCHEMBL5492543 | 0.82 | ALDH1A1 (0.46) | MEN1KMT2ATDP1POLBPTGDR2 | |
| SCHEMBL2995971 | 0.81 | CYP1A2 (0.42) | MEN1KMT2ATDP1PTGDR2MAPT | |
| SCHEMBL2993623 | 0.81 | RAB9A (0.47) | MEN1KMT2ATDP1PTGDR2MAPT | |
| SCHEMBL7104071 | 0.80 | ALDH1A1 (0.41) | MEN1KMT2ATDP1POLBPTGDR2 | |
| SCHEMBL8391718 | 0.79 | ALDH1A1 (0.38) | MEN1KMT2ATDP1PTGDR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624377-B1 | Lysosomal enzyme-cleavable antitumor drug conjugates | BRISTOL MYERS SQUIBB CO (US) | 2002-01-23 | — | — | EP | disclosed |
| US-6214345-B1 | ANTITUMOR AGENTS; DRUG CONJUGATES WHICH ARE SELECTIVELY ACTIVATIBLE AT THE SITE OF THE TUMOR | BRISTOL-MYERS SQUIBB CO. | 2001-04-10 | — | — | US | disclosed |
| EP-0624377-A2 | Lysosomal enzyme-cleavable antitumor drug conjugates | Bristol-Myers Squibb Company (US) | 1994-11-17 | — | — | EP | disclosed |