SCHEMBL7604033

SCHEMBL7604033

COC(=O)c1ccc(CNC(=O)OCc2ccccc2)cc1O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLAU P00749 1/20 0.51
TDP1 Q9NUW8 2/20 0.49
CA12 O43570 1/20 0.49
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
CA7 P43166 1/20 0.49
PDK2 Q15119 1/20 0.49
PDK4 Q16654 1/20 0.49
CA9 Q16790 1/20 0.49
CA14 Q9ULX7 1/20 0.49
EGFR P00533 1/20 0.48
SRC P12931 1/20 0.48
ALDH1A1 P00352 2/20 0.48
KDM4E B2RXH2 1/20 0.48
GAA P10253 1/20 0.48
MAPT P10636 3/20 0.48
CYP3A4 P08684 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
LMNA P02545 2/20 0.47
HPGD P15428 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7604271 0.85 NPC1 (0.52) PLAUALDH1A1KDM4EGAAMAPT
SCHEMBL7372649 0.84 CYP3A4 (0.63) PLAUTDP1ALDH1A1KDM4EGAA
SCHEMBL6380001 0.81 TRPV1 (0.63) PLAUTDP1CA12CA7CA9
SCHEMBL4724265 0.81 HIF1A (0.55) PLAUTDP1ALDH1A1KDM4EMAPT
SCHEMBL4766309 0.80 SMN1; SMN2 (0.62) PLAUTDP1CA1CA2GAA
SCHEMBL17864888 0.79 LMNA (0.61) PLAUCA12CA1CA2CA9
SCHEMBL27625466 0.79 L3MBTL1 (0.56) PLAUALDH1A1MAPTL3MBTL1LMNA
SCHEMBL14401631 0.78 SMN1; SMN2 (0.56) CA12CA1CA2CA7PDK2
SCHEMBL14328797 0.78 L3MBTL1 (0.67) PLAUMAPTL3MBTL1LMNASMN1; SMN2
SCHEMBL191161 0.78 PLAU (0.68) PLAUMAPTL3MBTL1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7208322-B2 Sensor surfaces for detecting analytes AGILENT TECHNOLOGIES, INC. (US) 2007-04-24 US disclosed
US-7208322-B2 Sensor surfaces for detecting analytes AGILENT TECHNOLOGIES, INC. (US) 2007-04-24 US disclosed
US-7179659-B2 Detection of preferential particles in sample; obtain sample, incubate with sensor and substrate, monitor and measure response, evaluate for presence of particle AGILENT TECHNOLOGIES, INC. (US) 2007-02-20 US disclosed
US-7179659-B2 Detection of preferential particles in sample; obtain sample, incubate with sensor and substrate, monitor and measure response, evaluate for presence of particle AGILENT TECHNOLOGIES, INC. (US) 2007-02-20 US disclosed
EP-0920413-B1 BORONIC COMPOUND COMPLEXING REAGENTS AND COMPLEXES PROLINX INC (US) 2002-11-13 EP disclosed
EP-0920413-A1 BORONIC COMPOUND COMPLEXING REAGENTS AND COMPLEXES PROLINX, INC. (US) 1999-06-09 EP disclosed
EP-0915832-A1 BORONIC COMPOUND COMPLEXING REAGENTS AND HIGHLY STABLE COMPLEXES PROLINX, INC. (US) 1999-05-19 EP disclosed
US-5877297-A Boronic compound complexing reagents and highly stable complexes PROLINX, INC. (US) 1999-03-02 US disclosed
US-5872224-A Boronic compound complexing reagents and highly stable complexes PROLINX, INC. (US) 1999-02-16 US disclosed
US-5869623-A Boronic compound complexing reagents and complexes SYSTEMIX (US) 1999-02-09 US disclosed
US-5859210-A Boronic compound complexing reagents and complexes PROLINX, INC. (US) 1999-01-12 US disclosed
US-5847192-A Boronic compound complexing reagents and complexes PROLINX, INC. (US) 1998-12-08 US disclosed
US-5837878-A Boronic compound complexing reagents and highly stable complexes PROLINX, INC. (US) 1998-11-17 US disclosed
US-5777148-A Boronic compound complexing reagents and highly stable complexes PROLINX, INC. (US) 1998-07-07 US disclosed
US-5744627-A Boronic compound complexing reagents and complexes PROLINX, INC. (US) 1998-04-28 US disclosed
WO-1998005627-A1 BORONIC COMPOUND COMPLEXING REAGENTS AND HIGHLY STABLE COMPLEXES PROLINX, INC. (US) 1998-02-12 WO disclosed
WO-1998005629-A1 BORONIC COMPOUND COMPLEXING REAGENTS AND COMPLEXES PROLINX, INC. (US) 1998-02-12 WO disclosed