SCHEMBL7604271

SCHEMBL7604271

COC(=O)c1ccc(CNC(=O)OCc2ccccc2)cc1OCc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.52
PKM P14618 1/20 0.52
RAB9A P51151 1/20 0.52
MAPT P10636 2/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
FFAR4 Q5NUL3 1/20 0.51
PLAU P00749 1/20 0.49
GAA P10253 2/20 0.48
SGMS2 Q8NHU3 1/20 0.48
LMNA P02545 3/20 0.46
ALDH1A1 P00352 3/20 0.46
KDM4E B2RXH2 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
HPGD P15428 2/20 0.45
MAPK1 P28482 1/20 0.45
HTT P42858 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6559986 0.89 PLAU (0.52) NPC1PKMRAB9AMAPTL3MBTL1
SCHEMBL6559992 0.87 PLAU (0.50) NPC1PKMRAB9AMAPTL3MBTL1
SCHEMBL7604033 0.85 PLAU (0.51) MAPTL3MBTL1PLAUGAALMNA
Hydrochloric Acid SCHEMBL6289049 0.85 FFAR4 (0.55) NPC1PKMRAB9AFFAR4LMNA
SCHEMBL14524175 0.83 SGMS2 (0.49) NPC1PKMRAB9AMAPTL3MBTL1
SCHEMBL2773150 0.82 FFAR4 (0.57) NPC1PKMRAB9AFFAR4GAA
SCHEMBL4699386 0.82 FFAR4 (0.57) NPC1PKMRAB9AMAPTL3MBTL1
SCHEMBL14892610 0.81 FFAR4 (0.59) NPC1PKMRAB9AFFAR4GAA
SCHEMBL3962253 0.79 MAOB (0.61) NPC1RAB9AFFAR4GAALMNA
SCHEMBL6560278 0.79 POLB (0.57) GAASGMS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7208322-B2 Sensor surfaces for detecting analytes AGILENT TECHNOLOGIES, INC. (US) 2007-04-24 US disclosed
US-7208322-B2 Sensor surfaces for detecting analytes AGILENT TECHNOLOGIES, INC. (US) 2007-04-24 US disclosed
US-7179659-B2 Detection of preferential particles in sample; obtain sample, incubate with sensor and substrate, monitor and measure response, evaluate for presence of particle AGILENT TECHNOLOGIES, INC. (US) 2007-02-20 US disclosed
US-7179659-B2 Detection of preferential particles in sample; obtain sample, incubate with sensor and substrate, monitor and measure response, evaluate for presence of particle AGILENT TECHNOLOGIES, INC. (US) 2007-02-20 US disclosed
EP-0920413-B1 BORONIC COMPOUND COMPLEXING REAGENTS AND COMPLEXES PROLINX INC (US) 2002-11-13 EP disclosed
EP-0920413-A1 BORONIC COMPOUND COMPLEXING REAGENTS AND COMPLEXES PROLINX, INC. (US) 1999-06-09 EP disclosed
US-5877297-A Boronic compound complexing reagents and highly stable complexes PROLINX, INC. (US) 1999-03-02 US disclosed
US-5872224-A Boronic compound complexing reagents and highly stable complexes PROLINX, INC. (US) 1999-02-16 US disclosed
US-5869623-A Boronic compound complexing reagents and complexes SYSTEMIX (US) 1999-02-09 US disclosed
US-5859210-A Boronic compound complexing reagents and complexes PROLINX, INC. (US) 1999-01-12 US disclosed
US-5847192-A Boronic compound complexing reagents and complexes PROLINX, INC. (US) 1998-12-08 US disclosed
US-5837878-A Boronic compound complexing reagents and highly stable complexes PROLINX, INC. (US) 1998-11-17 US disclosed
US-5777148-A Boronic compound complexing reagents and highly stable complexes PROLINX, INC. (US) 1998-07-07 US disclosed
US-5744627-A Boronic compound complexing reagents and complexes PROLINX, INC. (US) 1998-04-28 US disclosed
WO-1998005629-A1 BORONIC COMPOUND COMPLEXING REAGENTS AND COMPLEXES PROLINX, INC. (US) 1998-02-12 WO disclosed