Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061269 | 0.87 | HPGD (0.43) | HPGDLMNAPOLBSLC6A3KMT2A | |
| SCHEMBL8063636 | 0.79 | HPGD (0.41) | HPGDLMNATDP1SLC6A3KMT2A | |
| SCHEMBL7604663 | 0.77 | SMN1; SMN2 (0.45) | HPGDPOLBKMT2AMEN1PTGS2 | |
| SCHEMBL5051228 | 0.75 | TDP1 (0.46) | HPGDLMNATDP1SLC6A3KMT2A | |
| SCHEMBL8063640 | 0.75 | HPGD (0.46) | HPGDLMNAPOLBKMT2AMEN1 | |
| SCHEMBL5052991 | 0.72 | LMNA (0.39) | HPGDLMNAPOLBTDP1SLC6A3 | |
| SCHEMBL8057007 | 0.70 | HPGD (0.42) | HPGDLMNAPOLBSLC6A3KMT2A | |
| SCHEMBL5054408 | 0.70 | TDP1 (0.46) | HPGDLMNATDP1SLC6A3KMT2A | |
| SCHEMBL5052976 | 0.69 | SLC6A3 (0.45) | HPGDLMNATDP1SLC6A3KMT2A | |
| SCHEMBL7611757 | 0.68 | GGH (0.47) | HPGDLMNAKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002515040-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |
| US-6011021-A | GLUTAMATE-DERIVED HYDROXYPHOSPHINYL DERIVATIVE. | GUILFORD PHARMACEUTICALS INC. (US) | 2000-01-04 | — | — | US | disclosed |