Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 15/20 | 0.47 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1377571 | 0.84 | FOLH1 (0.47) | FOLH1NAALAD2GRM3 | |
| SCHEMBL7607485 | 0.82 | FOLH1 (0.50) | FOLH1NAALAD2GRM3 | |
| SCHEMBL7607491 | 0.79 | FOLH1 (0.50) | FOLH1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL31379018 | 0.78 | FOLH1 (0.53) | FOLH1NAALAD2KDM4CKDM4APHF8 | |
| SCHEMBL7145291 | 0.77 | FOLH1 (0.52) | FOLH1NAALAD2CHRM1AKR1A1CHRM3 | |
| SCHEMBL1377573 | 0.76 | FOLH1 (0.50) | FOLH1KDM4CKDM4APHF8KDM2A | |
| SCHEMBL7608616 | 0.75 | CPA3 (0.56) | FOLH1NAALAD2KDM4CKDM4APHF8 | |
| SCHEMBL108166 | 0.74 | FOLH1 (0.76) | FOLH1NAALAD2KDM4CKDM4AKDM2A | |
| SCHEMBL1373581 | 0.74 | FOLH1 (0.57) | FOLH1NAALAD2GRM3 | |
| SCHEMBL2230782 | 0.73 | CHRM1 (0.76) | FOLH1NAALAD2CHRM1AKR1A1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514185-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-0949922-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-10-20 | — | — | EP | claimed |
| WO-1998013044-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |