Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA3 | P15088 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.50 |
| ▸ | KDM4A | O75164 | 2/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1374778 | 0.87 | CPA3 (0.58) | CPA3ALOX5FOLH1NAALAD2CYP1A2 | |
| SCHEMBL31379023 | 0.79 | ALOX5 (0.56) | CPA3ALOX5KDM4AKDM4CKDM5A | |
| SCHEMBL31379020 | 0.77 | ALOX5 (0.61) | CPA3ALOX5KDM4AKDM4CKDM5A | |
| SCHEMBL2368373 | 0.76 | CPA3 (0.55) | CPA3FOLH1NAALAD2CYP1A2 | |
| SCHEMBL1374305 | 0.75 | CPA3 (0.58) | CPA3ALOX5KDM4AKDM4CFOLH1 | |
| SCHEMBL7604450 | 0.75 | FOLH1 (0.47) | KDM4AKDM4CPHF8KDM2AFOLH1 | |
| SCHEMBL7350860 | 0.75 | CPA3 (0.71) | CPA3FOLH1CYP1A2 | |
| SCHEMBL1373532 | 0.74 | CPA3 (0.56) | CPA3ALOX5KDM4AKDM4CKDM5A | |
| SCHEMBL3963424 | 0.73 | CPA3 (1.00) | CPA3FOLH1NAALAD2CYP1A2 | |
| SCHEMBL29088272 | 0.73 | CPA3 (1.00) | CPA3FOLH1NAALAD2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514185-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-0949922-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-10-20 | — | — | EP | claimed |
| WO-1998013044-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |