Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610386 | 0.94 | CHRNB2 (0.45) | CHRNB2CHRNA4DRD2DRD3KMT2A | |
| SCHEMBL7605146 | 0.89 | CHRNB2 (0.42) | CHRNB2CHRNA4 | |
| SCHEMBL6138415 | 0.85 | CHRNB2 (0.51) | CHRNB2CHRNA4KMT2A | |
| SCHEMBL7610378 | 0.82 | RIPK1 (0.42) | CHRNB2CHRNA4 | |
| SCHEMBL6137939 | 0.80 | CHRNB2 (0.60) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL6291503 | 0.79 | CHRNB2 (0.59) | CHRNB2CHRNA4 | |
| SCHEMBL6138579 | 0.79 | CHRNB2 (0.50) | CHRNB2CHRNA4KMT2A | |
| SCHEMBL6138316 | 0.76 | CHRNB2 (0.47) | CHRNB2CHRNA4DRD2DRD3KMT2A | |
| SCHEMBL23778489 | 0.72 | OPRM1 (0.41) | — | |
| SCHEMBL6138339 | 0.72 | CHRNB2 (0.47) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170281-A1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | disclosed |