Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7615015 | 0.80 | GABRA1 (0.40) | ADORA1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL7610672 | 0.75 | ALDH1A1 (0.38) | ADORA1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL7613399 | 0.75 | CA12 (0.41) | KDM4EALDH1A1HTTMAPTHPGD | |
| SCHEMBL6730881 | 0.73 | NR1H2 (0.37) | ADORA1KDM4EALDH1A1HTTMAPT | |
| SCHEMBL336418 | 0.69 | TP53 (0.31) | KDM4EALDH1A1HTTMAPTHPGD | |
| SCHEMBL6930598 | 0.69 | HPGD (0.41) | ADORA1KDM4EALDH1A1HTTMAPT | |
| SCHEMBL336417 | 0.69 | MEN1 (0.34) | ADORA1KDM4EALDH1A1HTTHPGD | |
| SCHEMBL7610118 | 0.66 | COMT (0.41) | ALDH1A1MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL335087 | 0.64 | GABRA1 (0.37) | KDM4EALDH1A1HTTMAPTHPGD | |
| SCHEMBL9254096 | 0.61 | KDM4E (0.53) | ADORA1KDM4EALDH1A1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020031536-A1 | Cosmetic compositions based on 4,5-pyrazolinediones, novel 4,5-pyrazolinediones, process for their preparation and uses thereof | L'OREAL SA | 2002-03-14 | — | — | US | disclosed |
| US-6322775-B1 | FOR COLORING THE SKIN AND/OR THE HAIR; SIDE EFFECTS REDUCTION; STABILITY | L'OREAL S.A. (FR) | 2001-11-27 | — | — | US | disclosed |
| EP-0888306-B1 | COSMETIC COMPOSITIONS CONTAINING PYRAZOLIN-4,5-DIONES, NOVEL PYRAZOLIN-4,5-DIONES, PREPARATION METHODS THEREFOR AND USES THEREOF | OREAL (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0888306-A1 | COSMETIC COMPOSITIONS CONTAINING PYRAZOLIN-4,5-DIONES, NOVEL PYRAZOLIN-4,5-DIONES, PREPARATION METHODS THEREFOR AND USES THEREOF | L'OREAL (FR) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997035842-A1 | COSMETIC COMPOSITIONS CONTAINING PYRAZOLIN-4,5-DIONES, NOVEL PYRAZOLIN-4,5-DIONES, PREPARATION METHODS THEREFOR AND USES THEREOF | L'OREAL (FR) | 1997-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020031536-A1 | Cosmetic compositions based on 4,5-pyrazolinediones, novel 4,5-pyrazolinediones, process for their preparation and uses thereof | PPARD, PLIN5, PDK4 | ADORA1 1956/4885KDM4E 626/4885ALDH1A1 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.