Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.62 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.62 |
| ▸ | TGM2 | P21980 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.55 |
| ▸ | CTSS | P25774 | 6/20 | 0.54 |
| ▸ | CTSL | P07711 | 5/20 | 0.54 |
| ▸ | CTSB | P07858 | 2/20 | 0.54 |
| ▸ | CTSK | P43235 | 2/20 | 0.54 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.53 |
| ▸ | DPP4 | P27487 | 1/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12176970 | 0.96 | HTT (0.67) | HTTKEAP1NFE2L2TGM2LMNA | |
| SCHEMBL2391033 | 0.90 | LMNA (0.65) | HTTKEAP1NFE2L2TGM2LMNA | |
| SCHEMBL18254066 | 0.88 | HTT (0.81) | HTTKEAP1NFE2L2TGM2LMNA | |
| SCHEMBL9975659 | 0.87 | CTSL (0.56) | HTTTGM2FOLH1CTSSCTSL | |
| SCHEMBL6444986 | 0.87 | HTT (0.67) | HTTKEAP1NFE2L2TGM2LMNA | |
| SCHEMBL9340146 | 0.86 | HTT (0.79) | HTTKEAP1NFE2L2TGM2LMNA | |
| SCHEMBL15346534 | 0.86 | HTT (0.79) | HTTKEAP1NFE2L2TGM2LMNA | |
| SCHEMBL9874334 | 0.86 | HTT (0.79) | HTTKEAP1NFE2L2TGM2LMNA | |
| SCHEMBL7285301 | 0.86 | TGM2 (0.65) | HTTKEAP1NFE2L2TGM2LMNA | |
| SCHEMBL3151115 | 0.86 | TGM2 (0.65) | HTTKEAP1NFE2L2TGM2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212096-A2 | DRUG CONJUGATES AND METHODS OF DESIGNING THE SAME | Brenner, Sydney (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001013958-A2 | DRUG CONJUGATES AND METHODS OF DESIGNING THE SAME | BRENNER SYDNEY (US) | 2001-03-01 | — | — | WO | disclosed |