Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 8/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27647947 | 1.00 | ALDH1A1 (0.44) | ALDH1A1ATMHCAR2HPGDTSHR | |
| SCHEMBL12149989 | 0.87 | ALDH1A1 (0.45) | ALDH1A1ATMHCAR2HPGDTSHR | |
| SCHEMBL11516612 | 0.83 | PLA2G2A (0.44) | ALDH1A1ATMHPGDEPHX1SMN1; SMN2 | |
| SCHEMBL7548562 | 0.81 | ALDH1A1 (0.47) | ALDH1A1ATMHCAR2HPGDTSHR | |
| SCHEMBL30510660 | 0.80 | ALDH1A1 (0.45) | ALDH1A1ATMHCAR2HPGDTSHR | |
| SCHEMBL8656037 | 0.79 | EPHX1 (0.56) | EPHX1ACHE | |
| SCHEMBL8655067 | 0.79 | EPHX1 (0.56) | EPHX1ACHE | |
| SCHEMBL8655079 | 0.79 | EPHX1 (0.56) | EPHX1ACHE | |
| SCHEMBL8654902 | 0.79 | EPHX1 (0.56) | EPHX1ACHE | |
| SCHEMBL8655372 | 0.79 | EPHX1 (0.56) | EPHX1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | disclosed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | disclosed |