Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PDE7A | Q13946 | 8/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.49 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.49 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.49 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7608810 | 0.88 | HSD17B10 (0.53) | HSD17B10PDE7APDE4BPDE4DPDE7B | |
| SCHEMBL7606524 | 0.87 | PDE7A (0.54) | HSD17B10PDE7APDE4BPDE4DPDE7B | |
| SCHEMBL7605576 | 0.87 | PDE7A (0.48) | HSD17B10PDE7APDE4BPDE4DPDE7B | |
| SCHEMBL7633888 | 0.84 | PDE7A (0.45) | HSD17B10PDE7APDE4BPDE4DPDE7B | |
| SCHEMBL7605376 | 0.84 | ALDH1A1 (0.46) | HSD17B10PDE7APDE4BPDE4DPDE7B | |
| SCHEMBL7610000 | 0.84 | PDE7A (0.49) | HSD17B10PDE7APDE4BPDE4DPDE7B | |
| SCHEMBL7641380 | 0.83 | ALDH1A1 (0.52) | HSD17B10PDE7APDE4BPDE4DPDE7B | |
| SCHEMBL7605602 | 0.80 | MAPT (0.52) | PDE7AALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL7610947 | 0.79 | HSD17B10 (0.49) | HSD17B10PDE7APDE4BPDE4DPDE7B | |
| SCHEMBL7607907 | 0.79 | PDE7A (0.55) | HSD17B10PDE7APDE4BPDE4DPDE7B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |