Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 9/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.46 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.45 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.45 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605577 | 0.87 | HSD17B10 (0.53) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL7606524 | 0.84 | PDE7A (0.54) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL7610000 | 0.83 | PDE7A (0.49) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL7641380 | 0.77 | ALDH1A1 (0.52) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL7608810 | 0.76 | HSD17B10 (0.53) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL7608855 | 0.76 | PDE7A (0.48) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL31217501 | 0.76 | TXNRD1 (0.63) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL7607008 | 0.76 | ITGB2 (0.42) | PDE7AALDH1A1MAPT | |
| SCHEMBL2590213 | 0.74 | HSD17B10 (0.67) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL30780972 | 0.74 | HSD17B10 (0.67) | PDE7APDE4BPDE4DPDE7BHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |