Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1178475 | 0.91 | MEN1 (0.56) | POLBMEN1KMT2AHDAC1TP53 | |
| SCHEMBL1178554 | 0.86 | MEN1 (0.54) | POLBMEN1KMT2AHDAC1KDM4E | |
| SCHEMBL1178397 | 0.77 | MET (0.45) | MEN1KMT2AHDAC1KDM4E | |
| SCHEMBL1178083 | 0.77 | PTGES (0.47) | MEN1KMT2AHDAC1 | |
| SCHEMBL1194034 | 0.75 | MEN1 (0.53) | POLBMEN1KMT2AHDAC1TP53 | |
| SCHEMBL3705301 | 0.75 | HDAC1 (0.43) | POLBMEN1KMT2AHDAC1 | |
| SCHEMBL1177781 | 0.74 | PTGDR2 (0.37) | MEN1KMT2AHDAC1MAPTKDM4E | |
| SCHEMBL11140135 | 0.74 | POLB (0.74) | POLBMEN1KMT2AHDAC1TP53 | |
| SCHEMBL7601254 | 0.74 | POLB (0.55) | POLBMEN1KMT2AHDAC1TP53 | |
| SCHEMBL1177945 | 0.74 | MEN1 (0.42) | MEN1KMT2AHDAC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268625-B1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | Bayer Pharma AG (DE) | 2012-05-16 | — | — | EP | disclosed |