Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16457383 | 0.91 | MEN1 (0.54) | POLBHRH3MEN1KMT2AKDM4E | |
| SCHEMBL516950 | 0.91 | MEN1 (0.54) | POLBHRH3MEN1KMT2AKDM4E | |
| SCHEMBL7601248 | 0.87 | MEN1 (0.49) | POLBHRH3MEN1KMT2AKDM4E | |
| SCHEMBL517331 | 0.84 | MEN1 (0.52) | POLBHRH3MEN1KMT2AKDM4E | |
| SCHEMBL7601983 | 0.81 | ALDH1A1 (0.41) | POLBHRH3KDM4EALDH1A1SMN1; SMN2 | |
| Bicarbonate SCHEMBL16457190 | 0.80 | MEN1 (0.46) | POLBHRH3MEN1KMT2AKDM4E | |
| Bicarbonate SCHEMBL3691123 | 0.78 | PTGES (0.48) | POLBHRH3MEN1KMT2AKDM4E | |
| Bicarbonate SCHEMBL16457686 | 0.78 | MEN1 (0.44) | POLBHRH3MEN1KMT2AKDM4E | |
| Bicarbonate SCHEMBL16457548 | 0.78 | MEN1 (0.44) | POLBHRH3MEN1KMT2AKDM4E | |
| SCHEMBL7907646 | 0.78 | MEN1 (0.46) | HRH3MEN1KMT2AKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268625-B1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | Bayer Pharma AG (DE) | 2012-05-16 | — | — | EP | disclosed |