Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | CYP4Z1 | Q86W10 | 2/20 | 0.49 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.49 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3746070 | 0.91 | CYP4F2 (0.58) | ALOX5CYP4Z1CYP4F2CYP4A11TNF | |
| SCHEMBL3683771 | 0.85 | ALOX5 (0.46) | ALOX5GAAHDAC1HDAC6 | |
| SCHEMBL135908 | 0.82 | HDAC1 (0.51) | CYP4Z1ESR1GAASMN1; SMN2HDAC3 | |
| SCHEMBL2874963 | 0.82 | CYP4Z1 (0.48) | ALOX5CYP4Z1CYP4F11CYP4F12CYP4F2 | |
| SCHEMBL19900035 | 0.82 | CYP4Z1 (0.48) | ALOX5CYP4Z1CYP4F11CYP4F12CYP4F2 | |
| SCHEMBL2291044 | 0.80 | CYP4F2 (0.58) | ALOX5CYP4Z1CYP4F11CYP4F12CYP4F2 | |
| SCHEMBL8848081 | 0.80 | CYP4Z1 (0.49) | ALOX5CYP4Z1CYP4F11CYP4F12CYP4F2 | |
| SCHEMBL7604379 | 0.80 | CYP4Z1 (0.46) | ALOX5CYP4Z1CYP4F11CYP4F12CYP4F2 | |
| SCHEMBL3740648 | 0.79 | CYP4F2 (0.58) | CYP4Z1CYP4F2CYP4A11TNFAPP | |
| SCHEMBL9121505 | 0.79 | CYP4Z1 (0.53) | ALOX5CYP4Z1CYP4F11CYP4F12CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395919-B1 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION | 2002-05-28 | — | — | US | disclosed |
| EP-1070048-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-11-07 | — | — | EP | disclosed |
| CN-1304401-A | Calcilytic compounds | SMITHKINE BEECHAM CORP (US) | 2001-07-18 | — | — | CN | disclosed |
| EP-1070048-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999051569-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |