Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.60 |
| ▸ | NFATC1 | O95644 | 6/20 | 0.60 |
| ▸ | GSK3B | P49841 | 4/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.53 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.50 |
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2462725 | 0.83 | KDM4E (0.65) | HTR2ADYRK1ANFATC1GSK3BPDPK1 | |
| SCHEMBL25770095 | 0.80 | HTR2A (1.00) | HTR2ADYRK1ANFATC1GSK3BPDPK1 | |
| SCHEMBL25254037 | 0.77 | HTR2A (0.59) | HTR2ADYRK1ANFATC1GSK3B | |
| SCHEMBL19972700 | 0.77 | HTR2A (0.49) | HTR2ADYRK1ANFATC1GSK3BPDPK1 | |
| SCHEMBL14875491 | 0.76 | HTR2A (0.48) | HTR2ADYRK1ANFATC1GSK3BCDK2 | |
| SCHEMBL30461701 | 0.75 | DYRK1A (1.00) | HTR2ADYRK1ANFATC1GSK3BPDPK1 | |
| SCHEMBL25421202 | 0.75 | DYRK1A (1.00) | HTR2ADYRK1ANFATC1GSK3BPDPK1 | |
| SCHEMBL16801801 | 0.75 | HTR2A (0.47) | HTR2ADYRK1ANFATC1GSK3BHSD17B10 | |
| SCHEMBL18324770 | 0.75 | TDO2 (0.71) | HTR2ADYRK1ANFATC1GSK3BHSD17B10 | |
| SCHEMBL28037610 | 0.74 | KDM4E (0.53) | HTR2ADYRK1AGSK3BHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | claimed |
| EP-2001480-A2 | INDAZOLE COMPOUNDS | Abbott Laboratories (US) | 2008-12-17 | — | — | EP | claimed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | claimed |
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | claimed |
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| EP-2001480-A2 | INDAZOLE COMPOUNDS | Abbott Laboratories (US) | 2008-12-17 | — | — | EP | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
| WO-2007117465-A2 | INDAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | HTR2A 4030/4885DYRK1A 3722/4885NFATC1 394/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | HTR2A 4030/4885DYRK1A 3722/4885NFATC1 394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.