Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928589 | 0.91 | KEAP1 (0.53) | KEAP1NFE2L2KDM4EUSP7GAA | |
| SCHEMBL6925163 | 0.88 | KEAP1 (0.47) | KEAP1NFE2L2KDM4EHSD17B10GAA | |
| SCHEMBL741497 | 0.83 | KEAP1 (0.71) | KEAP1NFE2L2KDM4EHSD17B10USP7 | |
| SCHEMBL741136 | 0.77 | KEAP1 (0.47) | KEAP1NFE2L2KDM4EHSD17B10USP7 | |
| SCHEMBL742310 | 0.76 | L3MBTL1 (0.50) | KEAP1NFE2L2KDM4EHSD17B10USP7 | |
| SCHEMBL28608716 | 0.75 | KEAP1 (0.43) | KEAP1NFE2L2KDM4EHSD17B10USP7 | |
| SCHEMBL9864443 | 0.74 | USP7 (0.57) | KEAP1NFE2L2KDM4EHSD17B10USP7 | |
| SCHEMBL6921023 | 0.72 | CSNK2A2 (0.38) | KEAP1NFE2L2KDM4EGAAALDH1A1 | |
| SCHEMBL3610681 | 0.72 | KDM4E (0.42) | KEAP1NFE2L2KDM4EHSD17B10GAA | |
| SCHEMBL6925132 | 0.71 | KEAP1 (0.37) | KEAP1NFE2L2KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020037915-A1 | Compounds and compositons for treating C1s-mediated diseases and conditions | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037915-A1 | Compounds and compositons for treating C1s-mediated diseases and conditions | C1S, C1R, C9 | KEAP1 1151/4885NFE2L2 2121/4885KDM4E 4740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.