Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 9/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | USP47 | Q96K76 | 5/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741497 | 0.86 | KEAP1 (0.71) | USP7KEAP1NFE2L2KDM4EHSD17B10 | |
| SCHEMBL741136 | 0.80 | KEAP1 (0.47) | USP7KEAP1NFE2L2KDM4EHSD17B10 | |
| SCHEMBL742310 | 0.79 | L3MBTL1 (0.50) | USP7KEAP1NFE2L2KDM4EHSD17B10 | |
| SCHEMBL16863728 | 0.77 | USP7 (0.47) | USP7KDM4ECLK1DYRK1ADYRK1B | |
| SCHEMBL7606077 | 0.74 | KEAP1 (0.51) | USP7KEAP1NFE2L2KDM4EHSD17B10 | |
| SCHEMBL9865352 | 0.72 | KEAP1 (0.36) | USP7KEAP1NFE2L2KDM4EHSD17B10 | |
| SCHEMBL5243459 | 0.72 | KEAP1 (0.42) | USP7KEAP1NFE2L2KDM4EHSD17B10 | |
| SCHEMBL3819530 | 0.72 | KEAP1 (0.42) | USP7KEAP1NFE2L2USP47GRIA4 | |
| SCHEMBL9864770 | 0.70 | USP7 (0.42) | USP7KDM4ECLK1DYRK1ADYRK1B | |
| SCHEMBL9865123 | 0.69 | KEAP1 (0.35) | USP7KEAP1NFE2L2USP47GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481584-B2 | 1H-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-07-09 | — | — | US | disclosed |
| US-20120165311-A1 | 1H-THIENO[2,3-C]PYRAZOLE DERIVATIVES USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-06-28 | — | — | US | disclosed |
| US-4994485-A | Seed and soil fungi, bacteria | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1991-02-19 | — | — | US | disclosed |
| EP-0234622-B1 | NEW THIO COMPOUNDS HAVING FUNGICIDAL ACTIVITY | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1990-06-27 | — | — | EP | disclosed |
| EP-0234622-A1 | New thio compounds having fungicidal activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1987-09-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165311-A1 | 1H-THIENO[2,3-C]PYRAZOLE DERIVATIVES USEFUL AS KINASE INHIBITORS | MAP3K19, MAP3K1, MAP3K3 | USP7 3461/4885KEAP1 1587/4885NFE2L2 3342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.