Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857975 | 0.77 | ALDH1A1 (0.60) | ALDH1A1KMT2AMEN1TDP1POLB | |
| SCHEMBL27553288 | 0.75 | ALDH1A1 (0.58) | ALDH1A1KMT2AMEN1TDP1POLB | |
| SCHEMBL11311905 | 0.75 | KMT2A (0.60) | ALDH1A1KMT2AMEN1TDP1POLB | |
| SCHEMBL6340252 | 0.75 | KMT2A (0.61) | ALDH1A1KMT2AMEN1TDP1POLB | |
| SCHEMBL156257 | 0.75 | ALDH1A1 (0.58) | ALDH1A1KMT2AMEN1TDP1POLB | |
| SCHEMBL181841 | 0.74 | ALDH1A1 (0.74) | ALDH1A1KMT2AMEN1TDP1POLB | |
| SCHEMBL3953437 | 0.74 | ALDH1A1 (0.73) | ALDH1A1KMT2AMEN1TDP1POLB | |
| SCHEMBL16448326 | 0.72 | ALDH1A1 (0.55) | ALDH1A1KMT2AMEN1TDP1POLB | |
| SCHEMBL6049872 | 0.72 | ALDH1A1 (0.55) | ALDH1A1KMT2AMEN1TDP1POLB | |
| Methylisothiocyanate SCHEMBL6049882 | 0.72 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002523448-A | — | — | 2002-07-30 | — | — | JP | claimed |
| EP-1107758-A2 | USE OF PIPERIDINES AND/OR PIPERAZINES AS INHIBITORS OF P38-ALPHA KINASE | SCIOS INC. (US) | 2001-06-20 | — | — | EP | claimed |
| WO-2000012074-A2 | USE OF PIPERIDINES AND/OR PIPERAZINES AS INHIBITORS OF P38-ALPHA KINASE | SCIOS INC. (US) | 2000-03-09 | — | — | WO | claimed |