SCHEMBL7607183

SCHEMBL7607183

O=C(NCc1ccc2c(c1)OCO2)c1cccc(NC(=O)c2ccccc2-c2ccccc2)c1

nearest known ligand 0.66

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.66
MEN1 O00255 4/20 0.64
KMT2A Q03164 4/20 0.64
LMNA P02545 1/20 0.64
MAPK1 P28482 1/20 0.64
MMP13 P45452 1/20 0.64
AURKA O14965 1/20 0.59
HPGD P15428 3/20 0.59
TSHR P16473 2/20 0.59
POLB P06746 1/20 0.56
RAB9A P51151 1/20 0.55
ALDH1A1 P00352 4/20 0.55
PPARG P37231 1/20 0.55
MAPT P10636 1/20 0.54
NAMPT P43490 1/20 0.53
ALOX12 P18054 1/20 0.53
NPC1 O15118 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10107748 0.87 HPGD (0.66) MEN1KMT2ALMNAMAPK1MMP13
SCHEMBL7610932 0.85 CHRNB2 (0.60) LMNAMAPK1HPGDALDH1A1PPARG
SCHEMBL7613182 0.83 CHRNB2 (0.57) LMNAMAPK1HPGDALDH1A1PPARG
SCHEMBL7607114 0.83 CHRNB2 (0.58) LMNAMAPK1HPGDALDH1A1PPARG
SCHEMBL7612899 0.82 SENP1 (0.64) MEN1KMT2ALMNAMAPK1HPGD
SCHEMBL7611172 0.81 HTT (0.57) LMNAMAPK1HPGDALDH1A1PPARG
SCHEMBL7607213 0.80 HTT (0.61) MEN1KMT2ALMNAMAPK1HPGD
SCHEMBL7610512 0.80 L3MBTL1 (0.61) MEN1KMT2ALMNAMAPK1HPGD
SCHEMBL5334358 0.80 MEN1 (0.90) HSD17B10MEN1KMT2ALMNAMAPK1
SCHEMBL5335238 0.80 MEN1 (1.00) HSD17B10MEN1KMT2ALMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020032238-A1 Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments BOEHRINGER INGELHEIM PHARMA KG (DE) 2002-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020032238-A1 Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments MTTP, CETP, FABP1 HSD17B10 320/4885MEN1 4038/4885KMT2A 2379/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.