Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | EPOR | P19235 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.37 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7612363 | 0.92 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2LTA4HNPY5R | |
| SCHEMBL7612302 | 0.89 | ALOX5 (0.45) | NPC1RAB9ASMN1; SMN2TRPM8EPOR | |
| SCHEMBL7768607 | 0.86 | SMN1; SMN2 (0.44) | NPC1RAB9ASMN1; SMN2LTA4HNPY5R | |
| SCHEMBL7609855 | 0.84 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2LTA4HNPY5R | |
| SCHEMBL7612156 | 0.84 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2LTA4HNPY5R | |
| SCHEMBL7610964 | 0.83 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2LTA4HTSHR | |
| SCHEMBL6322792 | 0.83 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2LTA4HTSHR | |
| SCHEMBL6324058 | 0.81 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2LTA4HNPY5R | |
| SCHEMBL7611594 | 0.80 | MAPT (0.48) | NPC1RAB9ASMN1; SMN2NPY5RALDH1A1 | |
| SCHEMBL7611651 | 0.80 | ALDH1A1 (0.42) | NPC1RAB9ASMN1; SMN2TRPM8EPOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230210-A1 | AMINOALCOHOL DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001036375-A1 | AMINOALCOHOL DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-05-25 | — | — | WO | disclosed |