Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7161466 | 0.82 | HRH3 (0.41) | HRH2HRH1SMN1; SMN2SIGMAR1HRH3 | |
| SCHEMBL7246376 | 0.80 | CYP1A2 (0.45) | HRH2HRH1HRH3ALDH1A1KDM4E | |
| SCHEMBL1719282 | 0.76 | ALDH1A1 (0.35) | MEN1KMT2AALDH1A1KDM4ERAB9A | |
| SCHEMBL2573857 | 0.74 | ALDH1A1 (0.40) | SMN1; SMN2SIGMAR1HRH3MEN1KMT2A | |
| SCHEMBL4500330 | 0.73 | PHGDH (0.36) | HRH2HRH1SMN1; SMN2CXCR4HRH3 | |
| SCHEMBL2621583 | 0.73 | SMN1; SMN2 (0.49) | HRH2HRH1SMN1; SMN2CXCR4SIGMAR1 | |
| SCHEMBL7607650 | 0.72 | HRH2 (0.41) | HRH2HRH1SMN1; SMN2CXCR4SIGMAR1 | |
| SCHEMBL4500328 | 0.72 | HRH2 (0.41) | HRH2HRH1SMN1; SMN2CXCR4SIGMAR1 | |
| SCHEMBL4754794 | 0.71 | SMN1; SMN2 (0.35) | SMN1; SMN2SIGMAR1 | |
| SCHEMBL5492084 | 0.70 | CNR2 (0.35) | SMN1; SMN2HRH3MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102743-B1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2002-07-24 | — | — | EP | claimed |