Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4683645 | 0.72 | RAB9A (0.32) | HPGD | |
| SCHEMBL5127782 | 0.72 | HRH3 (0.39) | CYP2D6HRH3KDM4EALDH1A1MEN1 | |
| SCHEMBL7607654 | 0.70 | HRH2 (0.38) | HRH3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7246376 | 0.70 | CYP1A2 (0.45) | HRH3KDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL1097459 | 0.68 | KMT2A (0.36) | CNR2HRH3HPGDKDM4EALDH1A1 | |
| SCHEMBL23634952 | 0.67 | HPGD (0.41) | HRH3HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL13202682 | 0.67 | HPGD (0.41) | HRH3HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL7161466 | 0.67 | HRH3 (0.41) | CYP2D6HRH3HPGDKDM4EALDH1A1 | |
| SCHEMBL2850740 | 0.66 | PAOX (0.37) | CNR2HRH3HPGDALDH1A1MEN1 | |
| SCHEMBL27956322 | 0.66 | FDPS (0.35) | MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218353-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2007-10-17 | — | — | EP | claimed |