Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 2/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19491082 | 0.70 | CYP3A4 (0.45) | ALDH1A1TSHR | |
| SCHEMBL15494105 | 0.69 | ATM (0.53) | ALDH1A1TSHRATML3MBTL1 | |
| SCHEMBL12803397 | 0.69 | ATM (0.53) | ALDH1A1TSHRATML3MBTL1 | |
| SCHEMBL15494121 | 0.68 | CYP2C19 (0.43) | ALDH1A1TSHR | |
| SCHEMBL7605214 | 0.68 | KDM4E (0.38) | ALDH1A1TDP1 | |
| SCHEMBL19490704 | 0.64 | TAAR1 (0.44) | SLC6A3SLC6A2SLC6A4 | |
| Phenylalanine Methyl Ester SCHEMBL9355479 | 0.63 | LAP3 (0.58) | ALDH1A1LMNAANPEPATM | |
| Phenylalanine Methyl Ester SCHEMBL9355493 | 0.63 | LAP3 (0.58) | ALDH1A1LMNAANPEPATM | |
| SCHEMBL5059759 | 0.63 | MMP1 (0.45) | ANPEPERAP2ATM | |
| SCHEMBL7928411 | 0.63 | MMP1 (0.40) | ANPEPERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002515040-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |