Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17563242 | 0.71 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2TDP1MEN1KMT2A | |
| SCHEMBL17563241 | 0.71 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2TDP1MEN1KMT2A | |
| SCHEMBL17563460 | 0.71 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2TDP1MEN1KMT2A | |
| SCHEMBL7607754 | 0.68 | SLC6A3 (0.39) | ALDH1A1TDP1 | |
| SCHEMBL10297360 | 0.68 | GSR (0.41) | ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL27721872 | 0.68 | BCHE (0.61) | ALDH1A1 | |
| SCHEMBL8443479 | 0.68 | CTSS (0.53) | EPHX2KMT2A | |
| SCHEMBL16248467 | 0.67 | GSR (0.43) | ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL16248460 | 0.67 | GSR (0.43) | ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL1322055 | 0.66 | SLC18A3 (0.56) | SLC18A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002515040-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |