Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7806313 | 0.82 | ALDH1A1 (0.58) | ALDH1A1CYP3A4CYP2C9CYP1A2CYP2D6 | |
| SCHEMBL11116125 | 0.80 | NPC1 (0.60) | ALDH1A1CYP3A4CYP2C9CYP1A2CYP2D6 | |
| SCHEMBL7133883 | 0.79 | ALDH1A1 (0.49) | ALDH1A1HPGDDRD2DRD3PDK2 | |
| SCHEMBL1806237 | 0.79 | ALDH1A1 (0.51) | ALDH1A1CYP3A4CYP2C9CYP1A2CYP2D6 | |
| SCHEMBL31471960 | 0.79 | DRD2 (0.46) | DRD2DRD3KCNH2CYP11B1CYP11B2 | |
| SCHEMBL5113275 | 0.79 | ALOX5 (0.59) | ALDH1A1CYP3A4CYP2C9CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL6393637 | 0.78 | DRD2 (0.46) | DRD2DRD3KCNH2CYP11B1CYP11B2 | |
| SCHEMBL2439728 | 0.77 | NOTUM (0.50) | DRD2DRD3KCNH2DHFRNOTUM | |
| SCHEMBL18725995 | 0.77 | DRD2 (0.52) | DRD2DRD3KCNH2CYP11B1CYP11B2 | |
| SCHEMBL20956923 | 0.77 | DRD2 (0.49) | DRD2DRD3KCNH2DHFRNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863872-B1 | PREPARATION OF CHIRAL 3-HYDROXY-2-PYRROLIDINONE DERIVATIVES | SYNGENTA LTD (GB) | 2002-05-29 | — | — | EP | disclosed |
| EP-1119547-A1 | SUBSTITUTED PYRROLIDINONE, THIAZOLIDINONE OR OXAZOLIDINONE AS HERBICIDES | Syngenta Limited (GB) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021928-A1 | SUBSTITUTED PYRROLIDINONE, THIAZOLIDINONE OR OXAZOLIDINONE AS HERBICIDES | SYNGENTA LIMITED (GB) | 2000-04-20 | — | — | WO | disclosed |