Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6507548 | 1.00 | ROCK2 (0.53) | ROCK2DRD2DRD3KCNH2ROCK1 | |
| SCHEMBL7604788 | 1.00 | ROCK2 (0.53) | ROCK2DRD2DRD3KCNH2ROCK1 | |
| SCHEMBL8789394 | 0.85 | ROCK2 (0.52) | ROCK2DRD2DRD3KCNH2ROCK1 | |
| SCHEMBL6510658 | 0.85 | ROCK2 (0.53) | ROCK2ROCK1HDAC6 | |
| SCHEMBL8788206 | 0.84 | ROCK2 (0.51) | ROCK2DRD2DRD3KCNH2ROCK1 | |
| SCHEMBL8788129 | 0.82 | ROCK2 (0.49) | ROCK2DRD2DRD3KCNH2ROCK1 | |
| SCHEMBL6508427 | 0.82 | CA12 (0.62) | DRD2DRD3KCNH2NOTUMCA12 | |
| SCHEMBL8787438 | 0.82 | ROCK2 (0.48) | ROCK2DRD2DRD3KCNH2ROCK1 | |
| SCHEMBL7604476 | 0.81 | NOTUM (0.52) | ROCK2DRD2DRD3KCNH2ROCK1 | |
| SCHEMBL8787922 | 0.81 | DRD2 (0.50) | ROCK2DRD2DRD3KCNH2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863872-B1 | PREPARATION OF CHIRAL 3-HYDROXY-2-PYRROLIDINONE DERIVATIVES | SYNGENTA LTD (GB) | 2002-05-29 | — | — | EP | disclosed |
| US-5710283-A | Preparation of chiral pyrrolidinone derivatives | ZENECA LIMITED (GB) | 1998-01-20 | — | — | US | disclosed |