Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 6/20 | 0.38 |
| ▸ | NAALAD2 | Q9Y3Q0 | 4/20 | 0.38 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | GNPAT | O15228 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129578 | 0.87 | SMN1; SMN2 (0.50) | FOLH1NAALAD2RIMKLAACEKDM4E | |
| SCHEMBL3792833 | 0.87 | SMN1; SMN2 (0.50) | FOLH1NAALAD2RIMKLAACEKDM4E | |
| SCHEMBL22612669 | 0.87 | SMN1; SMN2 (0.50) | FOLH1NAALAD2RIMKLAACEKDM4E | |
| SCHEMBL31167431 | 0.82 | ACE (0.32) | FOLH1NAALAD2RIMKLAACEKDM4E | |
| SCHEMBL11100413 | 0.82 | ACE (0.32) | FOLH1NAALAD2RIMKLAACEKDM4E | |
| SCHEMBL20388609 | 0.82 | ACE (0.32) | FOLH1NAALAD2RIMKLAACEKDM4E | |
| SCHEMBL1129467 | 0.82 | NOD1 (0.36) | FOLH1NAALAD2RIMKLAACEKDM4E | |
| SCHEMBL31675998 | 0.82 | NOD1 (0.47) | FOLH1NAALAD2RIMKLAACENOD1 | |
| SCHEMBL31112112 | 0.82 | NOD1 (0.47) | FOLH1NAALAD2RIMKLAACENOD1 | |
| Hydrochloric Acid SCHEMBL11097645 | 0.81 | ACE (0.32) | FOLH1NAALAD2RIMKLAACEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | disclosed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | disclosed |