SCHEMBL7608732

SCHEMBL7608732

O=C(NOCc1ccccc1)Nc1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.59
RAB9A P51151 3/20 0.59
KMT2A Q03164 2/20 0.56
MEN1 O00255 1/20 0.56
EPHX1 P07099 2/20 0.55
EPHX2 P34913 2/20 0.55
TP53 P04637 1/20 0.55
TSHR P16473 1/20 0.55
CDK9 P50750 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
CLK4 Q9HAZ1 1/20 0.55
HDAC3 O15379 2/20 0.54
HDAC4 P56524 2/20 0.54
HDAC1 Q13547 2/20 0.54
HDAC7 Q8WUI4 2/20 0.54
HDAC2 Q92769 2/20 0.54
HDAC10 Q969S8 2/20 0.54
HDAC11 Q96DB2 2/20 0.54
HDAC8 Q9BY41 2/20 0.54
HDAC6 Q9UBN7 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1990363 0.87 NPC1 (0.69) NPC1RAB9AKMT2AEPHX2HDAC3
SCHEMBL28230418 0.84 NPC1 (0.57) NPC1RAB9AEPHX2TSHRSMN1; SMN2
SCHEMBL7617377 0.83 TRPV1 (0.56) NPC1RAB9AKMT2AMEN1CA12
SCHEMBL8090351 0.82 MEN1 (0.66) RAB9AKMT2AMEN1SMN1; SMN2CA12
SCHEMBL14771799 0.81 NPC1 (0.62) NPC1RAB9AEPHX2HDAC3CA12
SCHEMBL28643940 0.80 TP53 (0.57) NPC1RAB9AKMT2AMEN1EPHX1
SCHEMBL27705808 0.80 NPC1 (0.61) NPC1RAB9AKMT2AEPHX2HDAC3
SCHEMBL22499774 0.80 EPHX1 (0.57) NPC1RAB9AKMT2AMEN1EPHX1
SCHEMBL9781781 0.80 NPC1 (0.61) NPC1RAB9AEPHX2HDAC3CA12
SCHEMBL27468596 0.79 NPC1 (0.59) NPC1RAB9AKMT2AMEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0777471-B1 INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES MINNESOTA MINING & MFG (US) 2002-11-27 EP disclosed
US-5663039-A AT LEAST A PORTION OF THE SURFACE IS COVERED WITH AN ADDITIVE SELECTED FROM THE GROUP CONSISTING OF A SULFITE, A HYDROXYLAMINE OR A BENZOIC OR SULFONIC ACID COMPOUND KONICA CORPORATION (JP) 1997-09-02 US disclosed
EP-0777471-A1 INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-06-11 EP disclosed
US-5612377-A OXYUREA DERIVATIVE MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-03-18 US disclosed
WO-1996003983-A1 INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-02-15 WO disclosed